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Location & Overview
The flexor pollicis longus muscle is located in the anterior part of the forearm and is one of the three deep flexor muscles found in the volar compartment of the forearm. The other two muscles in this compartment are the flexor digitorum profundus and pronator quadratus. This muscle lies deep to the radial head of the flexor digitorum superficialis muscle and is distal to the supinator muscle. Its primary function is to flex the thumb, making it a key muscle for gripping. Despite being located in the forearm, the flexor pollicis longus is classified as one of the extrinsic muscles of the hand.[1,2,3]
In Latin, ‘pollicis’ means ‘of the thumb’, ‘flexor’ means ‘a muscle that flexes a joint’, and ‘longus’ means ‘long’. Translated into English, flexor pollicis longus is ‘long flexor muscle of the thumb’.
Anatomical variation may occur in the form of an accessory head of flexor pollicis longus, often referred to as Gantzer’s muscle. A meta-analysis of cadaveric studies reported a pooled prevalence of approximately 48% for the accessory head of flexor pollicis longus, although estimates varied between studies, and the unit of analysis was upper limbs rather than individuals. This variant may be clinically relevant because of its anatomical relationship to the anterior interosseous nerve.[4]


Origin & Insertion
The flexor pollicis longus originates on the anterior surface of the radius (also known as the volar aspect), just distal to the radial tuberosity. It also originates from the adjacent interosseous membrane. The interosseous membrane is a strong fibrous sheet that connects the radius and ulna, which run parallel to each other in the forearm. The flexor pollicis longus also passes deep to the flexor retinaculum, also known as the transverse carpal ligament. The muscle then proceeds toward its insertion on the palmar aspect of the base of the distal phalanx of the thumb.[1,2,3]




Action & Function
The flexor pollicis longus muscle is the primary flexor of the thumb. It provides flexion at both the metacarpophalangeal and interphalangeal joints. In addition to thumb flexion, it can support other muscles by contributing weak flexion of the wrist joint.[1,2]


Innervation
The flexor pollicis longus is innervated by the anterior interosseous nerve. The anterior interosseous nerve is a branch of the median nerve. The median nerve passes between the two heads of the pronator teres muscle before giving rise to the anterior interosseous nerve.[1,2]

Blood Supply
Blood is supplied to the flexor pollicis longus by the anterior interosseous artery. The anterior interosseous artery branches from the common interosseous artery, which branches from the ulnar artery. Branches of the median artery also provide blood to the pre-digital portion of the flexor pollicis longus. The digital portion of the tendon receives its blood supply from the vincula V1 and V2. V1 originates from either the princeps pollicis artery or both digital arteries. V2 originates from both digital arteries.[1,2]
References
- [1] Moore KL, Agur AMR, Dalley AF. Clinically Oriented Anatomy. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2017
- [2] Benson DC, Miao KH, Varacallo M. Anatomy, Shoulder and Upper Limb, Hand Flexor Pollicis Longus Muscle. (Updated 2021 Jul 26). In: StatPearls (Internet). Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538490/
- [3] Standring S. (2015). Gray’s Anatomy: The Anatomical Basis of Clinical Practice, 41st Edn. Amsterdam: Elsevier.
- [4] Asghar, A., Jha, R. K., Patra, A., Chaudhary, B., & Singh, B. (2022). The prevalence and distribution of the variants of Gantzer’s muscle: a meta-analysis of cadaveric studies. Anat Cell Biol, 55(1), 3-13. https://doi.org/10.5115/acb.21.141
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